Inclisiran – How Does it Really Work?

Inclisiran – How Does it Really Work? Guest: R. Scott Wright, M.D. Host: Stephen Kopecky, M.D. (@DrSteveKopecky) In 2021, the U.S. Food and Drug Administration (FDA) approved the use of inclisiran to lower low-density lipoprotein (LDL) cholesterol in people with atherosclerotic cardiovascular disease. Joining us today to discuss inclisiran is R. Scott Wright, M.D., a cardiologist at Mayo Clinic in Rochester, Minnesota. Dr. Wright was intimately involved in planning recent studies of inclisiran and reporting the results. Specific topics discussed: How inclisiran works FDA-identified indications for use Administration and dosing Cost of the drug LDL cholesterol reduction results Initial and long-term side effects Long-term benefits and studies Inclisiran and lipoprotein (a) Off-target effects and drug-drug interaction monitoring The ideal patient and patients who are not appropriate to receive inclisiran Research outcomes for patients who are statin intolerant Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV. NEW Cardiovascular Education App:The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.