Longevity Papers 2025-03-27

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence Lu, J., Rao, S. R., Knowles, H. ... · cell biology · Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK · biorxiv Longevity Relevance Analysis (5) Bisphosphonates may trigger anti-aging effects by protecting against cellular senescence and modifying the plasma proteome. The paper addresses mechanisms that could potentially influence the root causes of aging, rather than merely treating age-related diseases. Wednesday, March 26, 2025 [11]Targeted intervention of senescence induced by a 5' half fragment of tRNASec(NCA) with antisense oligonucleotide extends healthspan and lifespan in mice Cao, K.-Y., Bai, L.-B., Zhang, D. ... · genetics · State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology · biorxiv Longevity Relevance Analysis (5) The paper claims that targeting the 5'-tRNASec(NCA) half with antisense oligonucleotides can ameliorate aging markers and extend healthspan and lifespan in mice. This research addresses a potential root cause of aging by identifying tRNA damage as a novel aging hallmark and proposing a therapeutic intervention, which is significant for the field of longevity research. Tuesday, March 25, 2025 [17]Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape. Sven Liesenfelder, Mohamed H Elsafi Mabrouk, Jessica Iliescu ... · Nature aging · Institute for Stem Cell Biology, RWTH Aachen University Medical School, Aachen, Germany. · pubmed Longevity Relevance Analysis (5) The paper claims that epigenetic editing at age-associated CpG sites can modulate the epigenetic aging network and interfere with epigenetic clocks. This research is relevant as it explores the mechanisms of aging at the epigenetic level, potentially addressing the root causes of aging rather than merely treating age-related diseases. Saturday, March 22, 2025 [45]Exosomes Released from Senescent Cells and Circulatory Exosomes Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid Signatures Patel, S. K., Bons, J., Rose, J. P. ... · cell biology · Buck Institute for Research on Aging · biorxiv Longevity Relevance Analysis (5) The paper identifies specific proteomic and lipidomic signatures in exosomes from senescent cells and human plasma that are associated with aging. This research is relevant as it explores the mechanisms of cellular senescence, which is a fundamental process in aging and age-related diseases, potentially leading to therapeutic targets for longevity interventions. Wednesday, March 26, 2025 [15]SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice Biashad, S. A., Hillpot, E., Morandini, F. ... · molecular biology · University of Rochester · biorxiv Longevity Relevance Analysis (4) Fucoidan supplementation activates SIRT6, leading to increased lifespan and reduced frailty in aged mice. The paper is relevant as it investigates a potential pharmacological approach to enhance longevity through the activation of a protein associated with lifespan extension and healthspan improvement. The podcast is auto-generated by NotebookLM and frankly, has occasional mistakes on the date of the paper and the authors, but mostly describes the overall idea of the research and papers well. I'm trying it out for a few weeks to see if it's worth continuing to generate the podcast.